Sunday, July 26

Chapter 1, Bureau Information

Dear beloved pharmacist....
Below is the new announcement made by NPCB…

Propylthiouracil
Methimazole
Carbimazole (prodrug of methimazole)

Are the drugs used for the treatment of HYPERTHYROIDISM due to Graves’ disease (an autoimmune disease).

However, FDA had been receiving many ADR report regarding the usage of these drugs which suggest the increased risk of hepatotoxicity and also death in adult and pediatric patients.
  • 32 cases of serious liver injury (12 deaths and 5 liver transplants occurred) associated with propylthiouracil use
  • 5 cases (3 deaths) of serious liver injury associated with methimazole usage

    Thus, close monitoring for sign and symptom of liver injury is essential especially during the first six months after initiation of therapy. If liver injury is suspected, the therapy should be promptly discontinued. Propylthiouracil should not be used in pediatric unless no other treatment options available. The therapy should be reserved only for:
  • 1st trimester pregnancy (no problem reported in the use of propylthiouracil in this patient)
  • Those who are allergic/intolerant to methimazole (meaning methimazole still the 1st line drug for hyperthyiroidism…)

2 Comments:

Anonymous said...

stefa isle yg ku kenal bkn mcm ni
so not u!
i want my old stefa isle back!!!!

stefa isle on July 27, 2009 at 5:42 PM said...

hehe.. dat intonation sound very familiar... dun worry.. i wil always treat u like i used 2b.. nothing change..i promise! =p haha

 

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